Skin Epidermal Thickness and Vascular Density in Type 1 Diabetes

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Abstract
Epidermal skin thickness and vascular density were assessed in skin biopsies obtained from the dorsum of the foot in 28 Type 1 diabetic patients and 17 normal control subjects, matched for age. Epidermal skin thickness did not differ significantly between control subjects (74 ± 4 (± SE) μ m) and diabetic patients (78 ± 4 μm). It was not related to the duration of diabetes and presence of complications. Neither small (capillary) nor large (arteriole/venule) vessel densities differed significantly between control subjects (59 ± 6 mm−2 and 19 ± 2 mm−2) and diabetic patients (65 ± 4 mm−2 and 22 ± 3 mm−2). Vessel densities were unrelated to the duration of diabetes and presence of complications.