Chorionic villi sampling changes maternal serum alpha-fetoprotein

1 January 1986

journal article
research article
Published by Wiley in Prenatal Diagnosis

Vol. 6 (1) , 69-73
https://doi.org/10.1002/pd.1970060110

Abstract

Second trimester amniocentesis has traditionally been utilized for prenatal genetic diagnosis. Chorionic villi sampling (CVS) is presently offered as an alternative. The occurrence of fetomaternal bleed (FMB) during CVS could increase the rate of post sampling abortion and, additionally, be of significance in patients at risk for isoimmunization. Detection and quantitation of FMB can be accomplished by the determination of changes in maternal serum alpha‐fetoprotein (MSAFP) before and after CVS.

Keywords

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