Central Lymphatic Irradiation to Low Dose for Advanced Nodular Lymphoreticular Tumors (Non-Hodgkin's Lymphoma)

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Abstract
Total central lymphatic irradiation (2500-3000 rads in 3-6 wk) including the entire abdomen, the supradiaphragmatic nodal areas, and Waldeyer''s ring was investigated as a potentially curative approach to patients with Stage III disease. Twenty-two patients were treated (24 mo. minimum observation). All evidence of disease disappeared in every patient. Three patients developed local recurrence; 2 received 2000 rads or less. Three patients had marginal recurrences, and 5 developed generalized disease involving viscera. Fourteen patients (64%) were alive and free of any evidence of disease from 24-90 mo. (median, 54 mo.). Absolute survival was 82% (18/22).