The DNA damage response: putting checkpoints in perspective
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- 23 November 2000
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 408 (6811) , 433-439
- https://doi.org/10.1038/35044005
Abstract
The inability to repair DNA damage properly in mammals leads to various disorders and enhanced rates of tumour development. Organisms respond to chromosomal insults by activating a complex damage response pathway. This pathway regulates known responses such as cell-cycle arrest and apoptosis (programmed cell death), and has recently been shown to control additional processes including direct activation of DNA repair networks.Keywords
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