CHANGES IN RNA CONTENT AND BASE COMPOSITION IN CORTICAL NEURONS OF RATS IN A LEARNING EXPERIMENT INVOLVING TRANSFER OF HANDEDNESS

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Abstract
The RNA content and base ratios of cortical neurons were studied in rats during transfer of handedness. Corresponding neurons in the contralateral part of the same cortex served as controls. The RNA content increased significantly in these neurons which have large nuclei relative to the cytoplasmic mass. The (G + C)/(A+U) ratio of the RNA decreased, indicating that the new RNA produced during learning is of the messenger type.