In vivo measurement of brain tumor pH using [11C]DMO and positron emission tomography
- 1 January 1985
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 17 (1) , 70-79
- https://doi.org/10.1002/ana.410170116
Abstract
In vivo measurements of regional brain tissue/tumor pH (rpH) have been accomplished in 9 patients with primary or metastatic brain tumors using[11C]dimethyloxazolidinedione ([11C]DMO) and positron emission tomography. Tumor rpH values ranged from 6.88 to 7.26, whereas gray matter and white matter rpH values ranged from 6.74 to 7.09 and from 6.77 to 7.03, respectively. Our result, which are consistent with reported [14C]DMO autoradiographic measurements of brain and tumor pH, suggest that the pH microenvironment of brain tumors is not more “acidic” than that of normal gray or white matter.This publication has 34 references indexed in Scilit:
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