Trimethoprim-Sulfamethoxazole in the Treatment of Carriers of Salmonella

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Abstract
Fifty-five cases of salmonellosis were observed, as either acute cases or asymptomatic carriers, over a span of four years. Twenty-eight cases were treated with antibiotics only or received no treatment; the treated group became negative for the infecting organisms after a mean time of 160 days, as compared with a mean of 52.4 days for those who were not treated. Twenty-seven other cases were treated with trimethoprim-sulfamethoxazole (TMP-SMZ) as the sole medication or after prior antibiotic therapy. Twenty-two of these cases (81.4%) were free of the infecting organism in a mean time of 18.75 days, whereas five cases failed to respond and cleared spontaneously in a mean time of 147.6 days. The beneficial effects of treatment with TMP-SMZ, as compared with antibiotics or no treatment at all are examined in the light of the need to protect the public from this potentially dangerous infection.

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