Capillary electrophoresis--a new clinical tool
Open Access
- 1 January 1991
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 37 (1) , 14-19
- https://doi.org/10.1093/clinchem/37.1.14
Abstract
The potential clinical diagnostic utility of capillary electrophoresis in an open-tubular column is established. Separation patterns for serum proteins by conventional agarose gel electrophoresis can be faithfully reproduced by a capillary electrophoresis procedure that provides the complete run data in 8 min. Hemoglobin variants can be separated within 10 min. The capillary electrophoresis separations are performed reliably and reproducibly in an untreated 75 micron (i.d.) x 25 cm fused-silica column. Diluted serum or hemoglobin samples can be loaded on an automated instrument with on-line injection, detection, and quantification, providing a truly "walkaway" electrophoresis system.Keywords
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