THE RATIONALE AND CLINICAL USE OF STEROID HORMONES IN CANCER

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Abstract
I. INTRODUCTION AND BACKGROUND A. The Cancer Problem and Its Association with Hormones A hundred years ago, when the average life expectancy was 34 years, death from cancer was a remote possibility. Today, when the life expectancy is about 64 years and increasing, cancer is an ever-present menace, since it is commonest in the older age groups (Ackerman and del Regato). In 1940 there were 170,000 deaths from cancer in the United States, thus making cancer second only to diseases of the circulatory system as a major cause of death. About 18% of all males and 22% of all females can be expected to harbor a cancer of some type during their lifetime (Dorn). Within recent years there has been a marked increase in cancer research directed toward the development of chemotherapeutic agents. The stimulus for these studies has been provided by the recognition of the limitations of surgery and

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