Direct and selective binding of an acidic transcriptional activation domain to the TATA-box factor TFIID
- 1 June 1990
- journal article
- Published by Springer Nature in Nature
- Vol. 345 (6278) , 783-786
- https://doi.org/10.1038/345783a0
Abstract
The potent transactivation domain of the herpes simplex virion protein VP16 was used as a column ligand for affinity chromatography. VP16 binds strongly and highly selectively to the human and yeast TATA box-binding factors. Our results imply that the principal target for acidic activation domains is the TATA-box factor TFIID.Keywords
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