Synthesis and Evaluation of Polyhydroxylated Near-Infrared Carbocyanine Molecular Probes
- 15 May 2004
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 6 (12) , 2067-2070
- https://doi.org/10.1021/ol049258a
Abstract
A new near-infrared (NIR) fluorescent molecular probe derived from indocarbocyanine dye and galactose was prepared, and the procedure was optimized. The presence of a nonionic polyhydroxyl moiety between hydrophobic groups enhances solubility and possibly minimizes aggregation in aqueous solutions. The structural framework of this molecule provides multivalent sites for labeling diverse molecules.Keywords
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