Studies on the Metabolism of Isoniazid in Subhuman Primates.

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Abstract
Tests for a polymorphism of isoniazid acetylation were performed in rhesus (Macaca mulatto) and cynomolgus (Macaca cynomolgus) monkeys and in mangabeys (Cercocebus fulliginosus) by studying the urinary excretion of isoniazid and its metabolites after intramuscular injection. In general, the patterns of metabolites excreted in urine of these species were qualitatively similar to those found previously in man. However, neither rhesus nor cynomolgus monkeys exhibited a polymorphism for isoniazid acetylation that is characteristic of human populations. Furthermore, rhesus monkeys showed no parallelism in capacities to acetylate isoniazid and sulfamethazine. Other results suggested that mangabeys exhibited a polymorphism for isoniazid acetylation.