EFFECT OF CENTRALLY ACTING DRUGS UPON MUSCULAR EXERCISE IN RATS

1 March 1959

journal article
research article
Published by Canadian Science Publishing in Canadian Journal of Biochemistry and Physiology

Vol. 37 (3) , 417-423
https://doi.org/10.1139/o59-043

Abstract

By means of a modified revolving-cage test, the effect of methylphenidate as compared with other centrally acting drugs has been studied in rats subjected to forced muscular exercise. Methylphenidate increased the performance of trained animals while amphetamine and ibogaine were inefficient. The running ability of untrained rats was also improved by the administration of methylphenidate. All the central nervous depressants tested (e.g., meprobamate, chlorpromazine and perphenazine) diminished the performance of animals at the dose utilized. This depressive action was counteracted by methylphenidate. Methylphenidate only antagonized perphenazine when the two agents were given in combination, before the animals were exposed to forced muscular exercise.

Keywords

This publication has 2 references indexed in Scilit:

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Annals of the New York Academy of Sciences, 1957
Die Papierelektrophorese von menschlichem Spermaplasma
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