Desoxyisoprenaline: an adrenoceptor stimulating and blocking agent

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Abstract
Desoxyisoprenaline (N-isopropyldopamine, DOI), an optically inactive analogue of isoprenaline, which lacks the alcoholic -OH group, was shown to stimulate β-adrenoceptors in cat papillary muscle, rat aorta and rat trachea, in addition to causing a hypotensive effect in anaesthetized cats. DOI was also shown to stimulate α-adrenoceptors in rat aorta. Furthermore, DOI blocked both α- and β-adrenoceptors in rabbit aortic strips and β-adrenoceptors in rat trachea. These different actions indicate that DOI has both adrenoceptor stimulating and blocking properties.

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