Renal Hyperconcentration of99mTc-HEDP in Experimental Acute Tubular Necrosis
- 1 May 1979
- journal article
- research article
- Published by Radiological Society of North America (RSNA) in Radiology
- Vol. 131 (2) , 491-495
- https://doi.org/10.1148/131.2.491
Abstract
The effect of transient renal ischemia on renal concentration and distribution of 99mTc-HEDP [Sn-hydroxy-ethylidine-diphosphonate], 99mTc-DMSA [dimercaptosuccinic acid] and 99mTc-DTPA [diethylene -triaminepentaacetic acid] was compared in rabbits with acute tubular necrosis. Scintigrams were obtained after injection in normal rabbits or ones with unilateral or bilateral ischemia. 99mTc-HEDP concentration in ischemic tissue was 8-18 times normal 1-4 h after injection, and the resulting images delineated the morphological changes in the ischemic kidneys more accurately than those obtained with DMSA or DTPA. Ca concentration in the ischemic kidneys increased 6-fold. 99mTC-HEDP may be useful in evaluation of renal failure secondary to tubular injury.This publication has 0 references indexed in Scilit: