Assignment of the X‐linked torsion dystonia gene to Xq21 by linkage analysis
- 1 September 1990
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 40 (9) , 1438
- https://doi.org/10.1212/wnl.40.9.1438
Abstract
We performed linkage analysis of X-linked torsion dystonia (XLTD) in 7 Filipino families, studying DNA from a total of 36 family members (9 obligate carrier females, and 18 affected and 9 unaffected males). Application of 21 informative X chromosomal DNA sequences allowed assignment of the XLTD locus to the proximal long arm of the X chromosome (Xq21). A maximum LOD score of 3.06 at ±= 0.0 was obtained with DXYS2, previously assigned to Xq21.3.This publication has 10 references indexed in Scilit:
- X-linked recessive torsion dystonia in the PhilippinesAmerican Journal of Medical Genetics, 1990
- Specific cloning of DNA fragments absent from the DNA of a male patient with an X chromosome deletion.Proceedings of the National Academy of Sciences, 1985
- Isolation of probes detecting restriction fragment length polymorphisms from X chromosome-specific libraries: potential use for diagnosis of Duchenne muscular dystrophyHuman Genetics, 1985
- The telomeric region of the human X chromosome long arm: presence of a highly polymorphic DNA marker and analysis of recombination frequency.Proceedings of the National Academy of Sciences, 1985
- Validity and reliability of a rating scale for the primary torsion dystoniasNeurology, 1985
- Genetic mapping of the human X chromosome by using restriction fragment length polymorphisms.Proceedings of the National Academy of Sciences, 1984
- A STRATEGY TO REVEAL HIGH-FREQUENCY RFLPS ALONG THE HUMAN X-CHROMOSOME1984
- A technique for radiolabeling DNA restriction endonuclease fragments to high specific activityAnalytical Biochemistry, 1983
- Single-copy sequence hybridizes to polymorphic and homologous loci on human X and Y chromosomes.Proceedings of the National Academy of Sciences, 1982
- CONSTRUCTION OF A GENETIC-LINKAGE MAP IN MAN USING RESTRICTION FRAGMENT LENGTH POLYMORPHISMS1980