Effect of Penicillin Dosage Schedule on Treatment of Experimental Typhoid Infections in Mice

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Abstract
When mice were infected with a relatively penicillin- resistant Salmonella typhosa, it was found that the penicillin PD50 varied with the treatment schedule. A smaller total amt. of penicillin was required for protection when the treatment was given as a single injn. than when 2, 3, 6, or 12 doses were divided equally within a 24-hr. period. When the time interval between 2 doses was varied from 2 to 36 hrs., the PD50 for the 2 dose 2-hr, schedule represented an even smaller total amt., and, therefore, a more economical use of penicillin than the single injn. schedule.

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