A Mutant Transcription Factor That is Activated by 3′:5′-Cyclic Guanosine Monophosphate
- 1 April 1973
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 70 (4) , 1017-1021
- https://doi.org/10.1073/pnas.70.4.1017
Abstract
We report here the isolation of an extragenic suppressor of a promoter mutation in the lactose operon of Escherichia coli . Genetic data have indicated that the suppressor of the P - mutation maps in the structural gene for the transcription factor catabolite activator protein. Biochemical studies suggest that the mutant molecules of catabolite activator protein are altered in such a way that they are activated by 3′:5′-cyclic GMP in addition to their normal effector, 3′:5′-cyclic AMP.Keywords
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