Extended-Spectrum Cephalosporinases in Enterobacteriaceae
- 1 January 2007
- journal article
- Published by Bentham Science Publishers Ltd. in Anti-Infective Agents
- Vol. 6 (1) , 71-82
- https://doi.org/10.2174/187152107779314133
Abstract
Extended-spectrum AmpC β-lactamases are derived from chromosomal cephalosporinases by amino acid deletion, insertion and replacement. These structural changes are responsible for an increased catalytic efficiency against extended- spectrum cephalosporins, such as ceftazidime, cefotaxime, cefepime, and cefpirome. An overview of the molecular and biochemical characterization of these identified β-lactamases in Enterobacteriaceae is provided. The structural modifications that account for the broadening substrate specificity and the phenotypes of resistance of the clinical isolates are detailed.Keywords
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