Schizophrenia Subdivided by the Family History of Affective Disorder

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Abstract
• Schizophrenics meetingDSM-IIIcriteria were divided, based on family history of affective disorder in first-degree relatives, into three groups:N-schizophrenics, no relative with affective disorder;U-schizophrenics, a relative with unipolar affective disorder; andB-schizophrenics, a relative with dipolar affective disorder. Although N- and U-schizophrenics displayed similar symptoms during the prodromal, actively psychotic, and remitted stages of their illness, U-schizophrenics were significantly more likely to have a depressive syndrome develop during the follow-up period. Compared with N-schizophrenics, B-schizophrenics were more depressed during the prodrome, were more elated and catatonic when actively psychotic, had fewer residual symptoms when remitted, and were much more likely to have a manic syndrome develop during the follow-up period. Even whenDSM-IIIcriteria are met, hesitation is indicated in diagnosing schizophrenia in patients with a first-degree relative with bipolar illness.

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