Circumvention of Herd Immunity during an Outbreak of Meningococcal Disease Could Be Correlated to Escape Mutation in the porA Gene of Neisseria meningitidis
Open Access
- 1 March 2001
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 69 (3) , 1971-1973
- https://doi.org/10.1128/iai.69.3.1971-1973.2001
Abstract
Meningococcal strains isolated during an outbreak were shown to belong to the ET-5 complex and to harbor a mutation in the VR2 region of the porA gene. They were less susceptible to the bactericidal effect of normal human serum than was the ET-5 wild-type strain. These results are of concern, as PorA is a potential target in vaccine design.Keywords
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