Prevalence of genosubtypes (PorA types) of serogroup B invasive meningococcus in the north of Spain from 2000 to 2003
- 1 April 2005
- journal article
- Published by Microbiology Society in Journal of Medical Microbiology
- Vol. 54 (4) , 381-384
- https://doi.org/10.1099/jmm.0.45855-0
Abstract
The composition of new vaccines against Neisseria meningitidis serogroup B is based on differences in the variable regions VR1 and VR2 of the class 1 outer-membrane protein (PorA) of meningococci. Genosubtyping of 96 N. meningitidis B isolates from blood or cerebrospinal fluid from 2000 to 2003 in the north of Spain allowed characterization of all the strains. Twenty-six genosubtypes or distinct PorA types were obtained. The most prevalent were P1.5-1, 10-8 (20 strains), P1.19, 15 (14 strains), P1.22, 9 (11 strains) and P1.5, 2 (nine strains), while 17 genosubtypes were represented by only one or two strains. The wide diversity of genosubtypes observed and their differences compared with those found in other regions reveals the difficulty in designing a useful outer-membrane vesicle vaccine applicable to different regions of the world.Keywords
This publication has 17 references indexed in Scilit:
- Analysis of PorA variable region 3 in meningococci: implications for vaccine policy?Vaccine, 2003
- Detection and genotyping of meningococci using a nested PCR approachJournal of Medical Microbiology, 2003
- Serum bactericidal activity and isotype distribution of antibodies in toddlers and schoolchildren after vaccination with RIVM hexavalent PorA vesicle vaccineVaccine, 2001
- Outer Membrane Protein Vesicle Vaccines for Meningococcal DiseasePublished by Springer Nature ,2001
- Effect of sequence variation in meningococcal PorA outer membrane protein on the effectiveness of a hexavalent PorA outer membrane vesicle vaccineVaccine, 2000
- Immunogenicity and safety of a hexavalent meningococcal outer-membrane-vesicle vaccine in children of 2–3 and 7–8 years of ageVaccine, 2000
- Class 1 outer membrane protein of Neisseria meningitidis: epitope analysis of the antigenic diversity between strains, implications for subtype definition and molecular epidemiologyMolecular Microbiology, 1993
- Effect of outer membrane vesicle vaccine against group B meningococcal disease in NorwayThe Lancet, 1991
- Definition of meningococcal class 1 OMP subtyping antigens by monoclonal antibodiesFEMS Microbiology Letters, 1988
- Whole-cell ELISA for typingNeisseria meningitidiswith monoclonal antibodiesFEMS Microbiology Letters, 1987