Influence of Reserpine on Cardiovascular and Sympatho-Adrenal Responses to Cyclopropane Anesthesia in the Dog

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Abstract
The cardiovascular and sympatho-adrenal responses to cyclopropane anesthesia were compared in normal and chronically reserpinized dogs. The results demonstrate the reserpine-treated animals are able to withstand concentrations of cyclopropane as high as those withstood by nontreated animals, even though mean aortic pressure, heart rate and increments in plasma levels of epinephrine were found to be significantly lower in the reserpine-treated animals. On the other hand, ventricular contractile force and aortic flow values were similar in both groups of animals at comparable levels of anesthesia.