Endocrine pancreatic control of the release of gastric inhibitory polypeptide

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Abstract
Intravenous infusion in anaesthetized rats of rat II C-peptide at a dose which produced circulating levels of 22.8±1.8 nmol/l after 30 min, resulted in a significant reduction (141±7 to 50±4 pmol/1, p<0.001, mean ± SEM) in the immunoreactive gastric inhibitory polypeptide response to an intestinal perfusion with a fat emulsion. Immunoreactive insulin levels were unchanged from basal in this study. It is suggested that C-peptide must be considered as a candidate for the endocrine pancreatic factor which exerts a negative feedback upon gastric inhibitory polypeptide release.