Patterns of glial proliferation during formation of olfactory glomeruli in an insect
- 1 January 1989
- Vol. 2 (1) , 10-24
- https://doi.org/10.1002/glia.440020103
Abstract
Paritioning of the first-order olfactory neuropil into glomeruli in the developing brain of the moth Manduca sexta occurs only in the presence of olfactory sensory axons and appears to be mediated by changes in glial cells (Oland et al.: J. Neurosci., 8:353–367, 1988). The arrival of sensory axons in the brain triggers changes in glial shape and position that lead to the formation of a glial scaffolding for the developing glomeruli. The presence of mitotic figures in glial cells at stages before glomeruli emerge (Oland and Tolbert: J. Comp. Neurol., 255:196–207, 1987) suggested that glial proliferation might also contribute to the formation of the glomerular envelopes. To determine whether glial proliferation is induced by olfactory axons, we have used 3H-thymidine to label dividing cells before, during, and after the formation of glomeruli and have compared the patterns of proliferation in normal and chronically unafferented olfactory neuropils. We found significant differences in mitotic indices only after glomerular walls had been established, indicating that the sensory axons induce the formation of glomerular envelopes primarily via the changes in glial morphology and distribution, not by stimulating glial proliferation.Keywords
This publication has 50 references indexed in Scilit:
- Afferent axons from the antenna influence the number and placement of intrinsic synapses in the antennal lobes of Manduca sextaSynapse, 1989
- Glycoconjugate boundaries during early postnatal development of the neostriatal mosaicJournal of Comparative Neurology, 1988
- Glial and glycoconjugate boundaries during postnatal development of the central nervous systemDevelopmental Brain Research, 1987
- A novel serotonin‐immunoreactive neuron in the antennal lobe of the sphinx moth Manduca sexta persists throughout postembryonic lifeJournal of Neurobiology, 1987
- Monoclonal antibody to glial fibrillary acidic protein reveals a parcellation of individual barrels in the early postnatal mouse somatosensory cortexBrain Research, 1986
- Schwann cells induce morphological transformation of sensory neurones in vitroNature, 1984
- Studies on the factors that govern directionality of axonal growth in the embryonic optic nerve and at the chiasm of miceJournal of Comparative Neurology, 1984
- Axolemma-enriched fractions isolated from PNS and CNS are mitogenic for cultured Schwann cellsDevelopmental Brain Research, 1982
- Astroglial cells provide a template for the positioning of developing cerebellar neurons in vitro.The Journal of cell biology, 1981
- Some observations on the early development of the optic tectum in the frog (Rana pipiens), with special reference to the effects of early eye removal on mitotic activity in the larval tectumJournal of Comparative Neurology, 1974