[D‐Ala2, Phe (p‐NO2)4, Leu5]Enkephalin Amide and Nα‐[D‐Ala2, Leu5]‐Enkephalyl‐Nε‐Acetyl‐Lysine Amide: Synthesis and Biological Properties of Prospective Enkephalin Cooperative‐Affinity and Photoaffinity Labels. Preliminary communication
- 7 March 1979
- journal article
- research article
- Published by Wiley in Helvetica Chimica Acta
- Vol. 62 (2) , 525-529
- https://doi.org/10.1002/hlca.19790620219
Abstract
As a study preliminary to attempts at photoaffinity and cooperative affinity labelling of cells and cell membrane vesicles bearing opiate receptors, the title compounds were prepared and tested by rat brain membrane binding assays and by a modified guinea‐pig ileum bio‐assay. The potency of the two compounds in both systems was considerably greater than that of the standard peptide, [Leu5]enkephalin, justifying further work with these and similar compounds.This publication has 29 references indexed in Scilit:
- Unsulfated C-terminal 7-peptide of cholecystokinin: A new ligand of the opiate receptorBiochemical and Biophysical Research Communications, 1978
- Conformation of [Leu5]Enkephalin from X-Ray Diffraction: Features Important for Recognition at Opiate ReceptorScience, 1978
- Hormone—receptor interactions: [4‐Carboranylalanine, 5‐leucine] ‐ enkephalin as a structural probe for the opiate receptorFEBS Letters, 1977
- Evidence for topographical analogy between methionine-enkephalin and morphine derivativesBiochemistry, 1977
- Hormone‐Receptor Interactions. Carboranylalanine (Car) as a Phenylalanine Analogue: Reactions with ChymotrypsinHelvetica Chimica Acta, 1977
- Synthesis and opioid activities of stereoisomers and other D-amino acid analogs of methionine-enkephalinBiochemical and Biophysical Research Communications, 1976
- Preferential conformation of the endogenous opiate-like pentapeptide met-enkephalin in DMSO-d6 solution determined by high field 1H NMRBiochemical and Biophysical Research Communications, 1976
- p‐nitrophenylalanine, p‐azidophenylalanine, m‐azidophenylalanine, and o‐nitro‐p‐azido‐phenylalanine as photoaffinity labelsFEBS Letters, 1974
- Conformation of Polypeptide ChainsAnnual Review of Biochemistry, 1969
- “Cross-β” conformation in proteinsJournal of Molecular Biology, 1968