Transient increase in the slow inward current following acetylcholine removal in catecholamine-treated guinea-pig Purkinje fibers.
Open Access
- 1 January 1984
- journal article
- Published by Physiological Society of Japan in The Japanese Journal of Physiology
- Vol. 34 (4) , 775-779
- https://doi.org/10.2170/jjphysiol.34.775
Abstract
In voltage-clamped guinea-pig Purkinje fibers, removal of acetylcholine (ACh) in the presence of isoproterenol produced a rebound increase in the slow inward current. This effect of ACh was abolished by atropine. These results are consistent with the hypothesis that cessation of the stimulation of myocardial muscarinic receptors transiently leads to enhanced activity of the beta-receptor/slow channel system in this tissue.Keywords
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