Inhibition of normal rat macrophage functions by soluble tumor products

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Abstract
The phagocytic and chemotactic activities of normal rat peritoneal macrophages were inhibited by sera from tumor-bearing rats (TBR) and 3 M KCl extracts of tumor mass. However, sera from Corynebacterium parvum [Propionibacterium acnes] or Listeria monocytogenes treated TBR did not inhibit phagocytosis. Sera from C. parvum-treated but not from L. monocytogenes-treated TBR still inhibited the chemotactic response of the normal macrophages; 3 M KCl extracts of tumors from C. parvum-treated TBR did not inhibit phagocytosis and chemotactic response of the same cells. Similar results were obtained with extracts of tumor masses from L. monocytogenes-treated rats. Treatment with bacterial immunomodulators can probably influence the release from neoplastic cells of soluble products influencing normal macrophage functions.