Genetic mapping of anhidrotic ectodermal dysplasia: DXS159, a closely linked proximal marker
- 1 October 1988
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 80 (2) , 177-180
- https://doi.org/10.1007/bf00702863
Abstract
Three families with anhidrotic ectodermal dysplasia (AED) have been studied by linkage analysis with seven polymorphic DNA markers from the Xp11-q21 region. Previously reported linkage to DXYS1 (Xq13-q21) has been confirmed (z(θ)=4.08 at θ=0.05) and we have also established linkage to another polymorphic locus, DXS159, located in Xq11-q12 (z(θ)=4.28 at θ=0.05). Physical mapping places DSX159 proximal to the Xq12 breakpoint of an X autosome translocation found in a female with clinical signs of ectodermal dysplasia. Of all markers that have been used in linkage analysis of AED, DXS159 would appear the closest on the proximal side of the disease locus.This publication has 21 references indexed in Scilit:
- Recognition and reanalysis of a cell line from a manifesting female with X linked hypohidrotic ectodermal dysplasia and an X; autosome balanced translocation.Journal of Medical Genetics, 1988
- Genetic mapping of nine DNA markers in the q11 → q22 region of the human X chromosomeGenomics, 1987
- Report of the Committee on Human Gene Mapping by Recombinant DNA techniques (Part 1 of 9)Cytogenetic and Genome Research, 1987
- Report of the committee on the genetic constitution of the X and Y chromosomesCytogenetic and Genome Research, 1987
- Manifestation of the lines of Blaschko in women heterozygous for X‐linked hypohidrotic ectodermal dysplasiaClinical Genetics, 1985
- Prenatal diagnosis of anhidrotic ectodermal dysplasiaPrenatal Diagnosis, 1984
- Assignment of a structural gene for?-glucuronidase to human chromosome C7Somatic Cell and Molecular Genetics, 1976
- Report of the Committee on the Genetic Constitution of the X ChromosomeCytogenetic and Genome Research, 1974
- A Stain for Sweat PoresNature, 1967
- Gene effect in carriers of anhidrotic ectodermal dysplasia.Journal of Medical Genetics, 1966