SENILE CEREBRAL AMYLOID - PRE-ALBUMIN AS A COMMON CONSTITUENT IN THE NEURITIC PLAQUE, IN THE NEUROFIBRILLARY TANGLE, AND IN THE MICRO-ANGIOPATHIC LESION

  • 1 January 1982
    • journal article
    • research article
    • Vol. 107  (1) , 41-50
Abstract
Formalin-fixed paraffin sections of affected brains were tested immunocytochemically for their reactivity against antiserum to prealbumin (recently disclosed as the major constituent of amyloid associated with familial amyloidotic polyneuropathy and senile cardiac amyloid) and known components of other types of amyloid (AA [amyloid + protein] AP [amyloid plasma component], etc.). Amyloid deposits in all 3 lesions reacted with anti-prealbumin, suggesting that it is a common constituent of these lesions. It is likely that prealbumin is the major constituent of amyloid associated with neuritic plaque, neurofibrillary tangle and microangiopathy in Alzheimer''s or Alzheimer-type dementia.