The fragile X chromosome in a large Indian kindred
- 23 April 1983
- journal article
- research article
- Published by Wiley in Clinical Genetics
- Vol. 23 (4) , 311-317
- https://doi.org/10.1111/j.1399-0004.1983.tb01883.x
Abstract
A large Indian kindred in which the fragile X chromosome is segregating was investigated in Cape Town, South Africa. Eight male hemizygotes and 4 female heterozygotes were mentally retarded. There is suggestive evidence that one deceased male of reportedly normal intelligence may have been a hemizygote. The existence of the fragile X syndrome in a number of different ethnic groups supports the contention that the gene controlling the phenotype and the fragile site are the same, or at least overlap.Keywords
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