Crystal structure at 2.8 Å resolution of a soluble form of the cell adhesion molecule CD2
- 1 November 1992
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 360 (6401) , 232-239
- https://doi.org/10.1038/360232a0
Abstract
The crystal structure of a soluble form of the T lymphocyte antigen CD2 provides the first complete view of the extracellular region of a cell adhesion molecule. The topology of the molecule, which comprises two immunoglobulin-like domains, is the same as that of the first two domains of CD4 but the relative domain orientation is altered by a fairly flexible linker region. The putative ligand-binding β-sheet forms a flat surface towards the top of the molecule. Crystal contacts between these surfaces suggest a plausible model for the adhesive interaction.Keywords
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