Acute Otitis Media in Children

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Abstract
IT has generally been assumed that viruses are involved in the pathogenesis of otitis media either as primary agents or as antecedents of bacterial infections, but neither of these possibilities has been well documented. This report presents the results of attempts to isolate viruses and mycoplasmas from middle-ear fluids obtained by needle aspiration in 90 children with acute otitis media, and results of serologic studies using 18 viral antigens and a Mycoplasma pneumoniae antigen in 73 of these children. The results of bacteriologic studies of the middle-ear fluids, throat and nasopharynx and a discussion of the clinical findings have been . . .