Biology and significance of T‐cell apoptosis in the liver
- 1 February 2002
- journal article
- review article
- Published by Wiley in Immunology & Cell Biology
- Vol. 80 (1) , 74-83
- https://doi.org/10.1046/j.1440-1711.2002.01065.x
Abstract
The liver has emerged as an organ with distinct immunological properties. In this review, we summarize evidence that shows that the liver can remove apoptotic, or non-apoptotic but activated, CD8+ T cells from the circulation and induce apoptosis in these activated T cells by either active or passive mechanisms. Hepatitis viruses, particularly hepatitis C virus, often establish persistent infection. We review evidence that suggests that these viruses exploit intrahepatic tolerance mechanisms to protect themselves from immune attack.Keywords
This publication has 100 references indexed in Scilit:
- TGF-β Released by Apoptotic T Cells Contributes to an Immunosuppressive MilieuImmunity, 2001
- Transforming growth factor‐β promotes ‘death by neglect’ in post‐activated human T cellsImmunology, 2001
- MATURE T LYMPHOCYTE APOPTOSIS—Immune Regulation in a Dynamic and Unpredictable Antigenic EnvironmentAnnual Review of Immunology, 1999
- Induction of peripheral CD8+ T‐cell tolerance by cross‐presentation of self antigensImmunological Reviews, 1998
- TRAIL/Apo-2-ligand-induced apoptosis in human T cellsEuropean Journal of Immunology, 1998
- Hepatocytes induce functional activation of naive CD8+ T lymphocytes but fail to promote survivalEuropean Journal of Immunology, 1998
- Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase AktScience, 1997
- Intercellular adhesion molecule‐1 expression on the hepatocyte membrane of patients with chronic hepatitis B and CLiver International, 1993
- The clearance of apoptotic cells in the liver is mediated by the asialoglycoprotein receptorFEBS Letters, 1992
- Prostanoid release of cultured liver sinusoidal endothelial cells in response to endotoxin and tumor necrosis factorJournal of Hepatology, 1990