Atrial natriuretic peptide (ANP) in rat gastrointestinal tract

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Abstract
Acid extracts of rat stomach and small intestine contained 8.6 ± 3.7 and 39 ± 15 ng/g of immunoreactive atrial natriuretic peptide (ANP). When studied by gel filtration and reverse‐phase high‐performance liquid chromatography, the stomach immunoreactivity consisted of multiple components, whereas the small intestine contained mostly proANP and ANP 1–28‐like material. These findings indicate that ANP may have a role in the physiology of the gastrointestinal tract, e.g. in the regulation of water and electrolyte absorption.