Changes induced by cold adaptation in the brown adipose tissue from several species of rodents, with special reference to the mitochondrial components

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Abstract
(1) The effects of cold adaptation upon the brown adipose tissue have been studied in rats, hamsters, mice, and guinea pigs.(2) Striking effects were found for total tissue as well as at the mitochondrial level, e.g., increases in protein and phospholipid contents, changes in phospholipid fatty acid composition (a decrease in the percentage of palmitic and palmitoleic acids and an increase in stearic and linoleic acids), and a change in the mitochondrial polypeptide composition (a marked increase in a 32 000 molecular weight polypeptide, except for hamsters).(3) In situations where animals exhibit a greatly enhanced capacity for nonshivering thermo-genesis (cold adaptation for rats, mice, and guinea pigs, birth for guinea pigs, and hibernation ability for hamsters, dormice, and garden dormice), brown fat mitochondria are characterized by the occurrence of large amounts of the 32 000 molecular weight polypeptide characteristic of these mitochondria.

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