EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS (EAE) IN 2 INBRED GUINEA-PIGS .1. STRAIN DIFFERENCES IN DEVELOPING CHRONIC RELAPSING FORM OF EAE

  • 1 January 1980
    • journal article
    • research article
    • Vol. 50  (3) , 173-178
Abstract
Two inbred strains of guinea pig (Strain 13 and JY-1) were compared with regard to their reactivity to the central nervous tissue emulsion in complete Freund''s adjuvant as the challenge for elicitation of EAE [experimental allergic encephalomyelitis]. The susceptibilities to EAE sensitization of adult guinea pigs were almost equal between the 2 strains, while those of young animals were different. The young Strain 13 guinea pigs are liable to develop chronic relapsing form of EAE; the incidence is 100% in 4-5 wk old guinea pigs and 60% in 6 wk old guinea pigs. Young JY-1 guinea pigs were as susceptible as adults. They developed typical acute EAE, which was usually fatal. Central nervous system of acute and chronic EAE guinea pigs of 2 strains was examined by the indirect immuunofluorescent technique for the detection of lymphocytes. Most of the positive lymphocytes were detected in the perivascular space and some were detected in the parenchyma of the brain.

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