Syntheses, analgetic activity and physical dependence capacity of 5-phenyl-6,7-benzomorphan derivatives
- 1 May 1979
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 22 (5) , 537-553
- https://doi.org/10.1021/jm00191a016
Abstract
Observations made during the Stevens'' rearrangement of 1-benzyl-1-methyl-.DELTA.3-piperidinium salt derivatives under various conditions are discussed. The absolute configuration of the 9-demethyl series and the 2''-deoxy series is established. A convenient synthesis of 3H-labeled phenols using 3H3PO4 is described, as well as the preparation of 14C-labeled compounds by conventional methods. Analgetic activity and physical dependence was examined in mice.This publication has 4 references indexed in Scilit:
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