Cellular and subcellular distribution of the S‐100 protein in rabbit and rat central nervous system

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Abstract
The cellular and subcellular distribution of the S‐100 protein in rabbit and rat central nervous system was studied both quantitatively and qualitatively. Microcomplement fixation estimations on bulk‐prepared neuronal and glial cells showed at least five to six times higher amounts of water‐soluble S‐100 protein. High levels of S‐100 protein were found in mitochondria and soluble protein fractions. Immunoelectron microscope investigations demonstrated S‐100 protein in neuronal structures, such as the postsynaptic membrane and part of the plasma membrane. Among glial cells the astrocytic filaments contained high levels of S‐100 protein. S‐100 was also found in most subcellular membranes of astrocytes and oligodendrocytes.