Microbial genome analysis: insights into virulence, host adaptation and evolution
- 1 October 2000
- journal article
- review article
- Published by Springer Nature in Nature Reviews Genetics
- Vol. 1 (1) , 30-39
- https://doi.org/10.1038/35049551
Abstract
Genome analysis of microbial pathogens has provided unique insights into their virulence, host adaptation and evolution. Common themes have emerged, including lateral gene transfer among enteric pathogens, genome decay among obligate intracellular pathogens and antigenic variation among mucosal pathogens. The advent of post-genomic approaches and the sequencing of the human genome will enable scientists to investigate the complex and dynamic interplay between host and pathogen. This wealth of information will catalyse the development of new intervention strategies to reduce the burden of microbial-related disease.Keywords
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