A NOVEL BAYESIAN DECISION PROCEDURE FOR EARLY-PHASE DOSE-FINDING STUDIES
- 11 January 1999
- journal article
- Published by Taylor & Francis in Journal of Biopharmaceutical Statistics
- Vol. 9 (4) , 583-597
- https://doi.org/10.1081/bip-100101197
Abstract
Phase I first-in-man studies in normal, healthy volunteers are performed to define a maximum safe dose and to identify a range of acceptable doses for later drug development studies in patients. An...Keywords
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