The immunopathology of Guillain-Barré syndrome
- 1 October 1996
- journal article
- review article
- Published by Wolters Kluwer Health in Current Opinion in Neurology
- Vol. 9 (5) , 329-333
- https://doi.org/10.1097/00019052-199610000-00002
Abstract
Identification of new antigens in different patterns of Guillain-Barré syndrome has led to new pathophysiological concepts of Guillain-Barré syndrome and the related Miller-Fisher syndrome. Patients with Guillain-Barré syndrome occurring after Campylobacter jejuni infection have been found to develop more frequently axonal and motor forms of the syndrome. Anti-GM1 antibodies decreased Na+ current in the presence of complement. In acute axonal Guillain-Barré syndrome, macrophages were found in the periaxonal space without damaging myelin sheath. Important epitopes may be localized on the axolemma, but further studies are needed to confirm these observations.Keywords
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