Specificity of Leucine Stimulation of Insulin Release

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Abstract
The ability of leucine to stimulate insulin release was studied in an in vitro system, using microdissected pancreatic islets with a high proportion of the insulin-producing β-cells. When tested in a glucose-free medium, L-leucine stimulated insulin release over a wide concentration range with maximum effect at about 20 mM. The stimulation of insulin release was additive to that elicited by 10 mM glucose. The L-configuration was essential for leucine to be recognized by the β-cells as an insulin secretagogue. L-isoleucine, alone or in combination with L-leucine, did not affect insulin release. It seems, therefore, unlikely that all sites for L-leucine transport are identical with receptor sites for stimulation of insulin release.

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