Interaction of preservatives with cetomacrogol
- 1 July 1971
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 23 (7) , 482-489
- https://doi.org/10.1111/j.2042-7158.1971.tb08694.x
Abstract
The interaction of a number of commonly used preservatives (benzoic acid, p-hydroxybenzoic acid, methyl p-hydroxybenzoate, propyl p-hydroxybenzoate and chloroxylenol with the non-ionic surfactant cetomacrogol was examined and a comparison made of various methods of expressing this interaction. It is suggested that the Scatchard equation is the most satisfactory equation for describing the binding data. Binding parameters determined from a Scatchard plot in the concentration range of free preservative appropriate for antimicrobial activity can be used to calculate the total concentration of preservative required in the surfactant system.Keywords
This publication has 21 references indexed in Scilit:
- Application of Molecular Sieve Technique in Solubilization Studies of Benzoic Acid in Solutions of Cetomacrogol 1000Journal of Pharmaceutical Sciences, 1970
- A model for the influence of emulsion formulation on the activity of phenolic preservativesJournal of Pharmacy and Pharmacology, 1969
- Potentiometric studies on solubilisation in non-ionic micellar solutions. Part II. Solubilisation of benzoic acid and the hydroxybenzoic acids and location of the solubilisatesJ. Chem. Soc. A, 1967
- The evaluation of a molecular sieve technique to determine the interaction between a preservative and a surfactantJournal of Pharmacy and Pharmacology, 1966
- Interaction of Preservatives with Macromolecules VJournal of Pharmaceutical Sciences, 1964
- 1180. Potentiometric studies on solubilisation in non-ionic micellar solutions. Part I. Interpretation of pH changes and mechanism of solubilisation of benzoic acidJournal of the Chemical Society, 1964
- Interaction of Parabens with Nonionic MacromoleculesJournal of Pharmaceutical Sciences, 1961
- Interaction of Sorbic Acid with Nonionic MacromoleculesJournal of Pharmaceutical Sciences, 1961
- The Effect of Ph on the Efficiency of Various Mold Inhibiting Compounds * *Flint, Eaton and Co., Decatur, Ill.Journal of the American Pharmaceutical Association (Scientific ed.), 1958
- The Release of Antimicrobial Agents from Solutions of Surface-Active AgentsJournal of the American Pharmaceutical Association (Scientific ed.), 1953