Metabolic Labeling of Sialic Acids in Living Animals with Alkynyl Sugars
- 12 May 2009
- journal article
- research article
- Published by Wiley in Angewandte Chemie International Edition in English
- Vol. 48 (22) , 4030-4033
- https://doi.org/10.1002/anie.200806319
Abstract
Sialome sweet sialome: As sialic acids are involved in many host–pathogen recognition events and are markers of embryonic and malignant tissues, there is great interest in methods for the enrichment and identification of sialylated glycoproteins from complex tissues. Now N‐(4‐pentynoyl)mannosamine can be used to metabolically label sialylated glycoproteins in living animals, enabling future identification of new biomarkers. magnified imageKeywords
This publication has 29 references indexed in Scilit:
- Combining Results from Lectin Affinity Chromatography and Glycocapture Approaches Substantially Improves the Coverage of the GlycoproteomeMolecular & Cellular Proteomics, 2009
- Tailored Glycoproteomics and Glycan Site Mapping Using Saccharide-Selective Bioorthogonal ProbesJournal of the American Chemical Society, 2007
- Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cellsProceedings of the National Academy of Sciences, 2007
- Glycoconjugate glycans as viral receptorsAnnals of Medicine, 2005
- A Strain-Promoted [3 + 2] Azide−Alkyne Cycloaddition for Covalent Modification of Biomolecules in Living SystemsJournal of the American Chemical Society, 2004
- Chemical remodelling of cell surfaces in living animalsNature, 2004
- Profiling Enzyme Activities In Vivo Using Click Chemistry MethodsChemistry & Biology, 2004
- A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal AlkynesAngewandte Chemie International Edition in English, 2002
- Cell Surface Engineering by a Modified Staudinger ReactionScience, 2000
- Exploiting altered glycosylation patterns in cancer: Progress and challenges in diagnosis and therapyTrends in Biotechnology, 1994