The Radio-Immunoassay of Follicle-Stimulating Hormone (FSH) During Human Pregnancy: Serum Concentration and Response to Luteinizing Hormone Releasing Factor (LRF)

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Abstract
Concentrations of follicle-stimulating hormone (FSH) detectable by radio-immunoassay and the FSH response to synthetic luteinizing hormone releasing factor (LRF) were measured in the sera of fourteen women during the first, the second and the third trimesters of pregnancy. Serum FSH was detectable, but relatively low in all the fourteen subjects throughout pregnancy. Moreover, exogenously administered synthetic LRF failed to stimulate serum FSH secretion from the anterior pituitary and there was no rise in serum FSH in all the fourteen pregnant women. Thus, it might be concluded that follicle-stimulating activity of the hypophyseal gland is suppressed throughout human pregnancy by an unknown mechanism.

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