Comparison of a GLC-NPD Method with a GLC-MS-SIM Procedure for the Determination of Tilidine and Its Metabolites in Plasma
- 30 June 1987
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Analytical Toxicology
- Vol. 11 (4) , 144-148
- https://doi.org/10.1093/jat/11.4.144
Abstract
A gas liquid chromatographic method with nitrogen-phosphorus detection (GLC-NPD) is compared to a GLC-mass spectrometric determination employing selected ion monitoring (GLC-MS-SIM). These two methods of gas chromatographic separation were shown to be suitable for therapeutic monitoring of tilidine, nortilidine, and bisnortilidine in patients. The pharmacokinetic profile of tilidine was also studied in three normal humans after a single oral dose. Pharmacokinetic parameters such as Cmax, tmax, (t1/2)β, AUC, AUMC, Vdβ, Cltot, β, and MRT are derived from model independent pharmacokinetic techniques.This publication has 3 references indexed in Scilit:
- The conversion of a standard gas chromatograph to a fused silica capillary system: Applications in human toxicology and tropical medicineJournal of Pharmaceutical and Biomedical Analysis, 1986
- GLC Determination of Tilidine, Nortilidine, and Bisnortilidine in Biological Fluids with a Nitrogen-Sensitive DetectorJournal of Pharmaceutical Sciences, 1978
- Doxepin kineticsClinical Pharmacology & Therapeutics, 1978