ANTAGONISMUS VON TESTOSTERON UND 1,2α-METHYLEN-6-CHLOR-PREGNA-4,6-DIEN-17α-OL-3,20-DION (CYPROTERON) AN DEN DIE GONADOTROPHIN-SEKRETION REGULIERENDEN ZENTREN BEI MÄNNLICHEN RATTEN

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Abstract
Following the administration of an androgen antagonist (1,2α-methylene6-chloro-pregna-4,6-diene-17α-ol-3,20-dione = cyproterone) to infantile rats, the inhibitory action of low doses of testosterone propionate, TP (0.003–0.03 mg) on the centers regulating the gonadotrophin secretion can be more or less prevented. The inhibitory action of 0.1 mg testosterone propionate cannot be influenced by 5 mg cyproterone. The direct stimulating action of high TP doses (0.3 mg and 1 mg) on the testes is inhibited by the androgen antagonist. These results are due to the difference in sensitivity to androgens of the centers regulating the gonadotrophin secretion on the one hand, and of the testes on the other.