Sequential Inferior Petrosal Venous Sampling for Cushing's Disease

Publisher Website
Google Scholar
Abstract
To the Editor: Bilateral simultaneous sampling of the inferior petrosal sinus for ACTH is reported to be a valuable technique in the localization of ACTH-secreting pituitary adenomas (Jan. 10 issue).1 We have become aware, however, from sampling pituitary effluent in horses, that peaks of ACTH and vasopressin secretion may be very transient (Redekopp C, et al.: unpublished data). The following case report demonstrates the importance of sequential sampling in the diagnosis of Cushing's disease.A 26-year-old woman acquired the clinical features of Cushing's syndrome over a three-year period. Investigations showed suppression of hypercortisolism during the high-dose dexamethasone suppression test and . . .