Amine Prodrugs Which Utilize Hydroxy Amide Lactonization. II. A Potential Esterase-Sensitive Amide Prodrug
- 1 January 1991
- journal article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 08 (4) , 455-461
- https://doi.org/10.1023/a:1015890809507
Abstract
In an effort to develop esterase-sensitive pro-prodrugs for amines, an amide derivative of 3-(2′-acetoxy-4′,6′-dimethylphenyl)-3,3- dimethylpropionic acid (4-methoxyaniline amide ( 8) was synthesized...Keywords
This publication has 10 references indexed in Scilit:
- Amine Prodrugs Which Utilize Hydroxy Amide Lactonization. I. A Potential Redox-Sensitive Amide ProdrugPharmaceutical Research, 1991
- Carboxylesterases in Rat and Human Sera and Their Relationship to Serum Aryl Acylamidases and CholinesterasesEuropean Journal of Biochemistry, 1983
- Pro‐drugs of amides, imides, and aminesMedicinal Research Reviews, 1981
- Human plasma prekallikrein. Studies of its activation by activated factor XII and of its inactivation by diisopropyl phosphofluoridateBiochemistry, 1980
- Rationale for Design of Biologically Reversible Drug Derivatives: ProdrugsJournal of Pharmaceutical Sciences, 1975
- Rationalization of the rate of the acylation step in chymotrypsin-catalyzed hydrolysis of amidesJournal of the American Chemical Society, 1975
- Stereopopulation control. II. Rate enhancement of intramolecular nucleophilic displacementJournal of the American Chemical Society, 1972
- Stereopopulation control. I. Rate enhancement in the lactonizations of o-hydroxyhydrocinnamic acidsJournal of the American Chemical Society, 1972
- Stereopopulation control. III. Facilitation of intramolecular conjugate addition of the carboxyl groupJournal of the American Chemical Society, 1972
- Reaction of Ficin with Diisopropylphosphorofluoridate. Evidence for a Contaminating Inhibitor*Biochemistry, 1965